Today, substances such as hyaluronic acid, calcium hydroxyapatite, polycaprolactone and poly-L-lactic acid are used for filling purposes. Among them, hyaluronic acid is the most commonly used, and it is used in almost every region of the face. Nose, lip, cheekbone, chin, nasolabial, temple and forehead are the areas where successful results are obtained for filling. Filling applications must be done by specially trained physicians in places with health institutions (such as hospitals, polyclinics and clinics). Be sure to ask your doctor for the sticker containing the brand, expiry date and Lot number of the filler used, and keep it. It is very important to know about the previously used filler material in the next application.